PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION
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Sep 12, 2024
app pub date -
Jun 10, 2022
filing date -
Jun 10, 2021
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Abstract
The invention provides compounds of formula (I), stereoisomers, and pharmaceutically acceptable salts thereof for use in the treatment or prevention of hypertension: wherein: R1 and R2 are independently selected from H, halogen, C1-6 alkyl, C1-6 haloalkyl, and —CN, provided that at least one of R1 and R2 is other than H; and R3 is a group of the formula: wherein: n is 0 or 1; R4 is H or C1-3 alkyl; L1 is a linking group selected from a bond, —(CH2)P— in which p is an integer from 1 to 3, and C3-6 cycloalkylene; and X is selected from: (i) an aryl group optionally substituted by one or more substituents selected from C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, halogen, and —CN; (ii) a 5 or 6-membered heterocyclic ring optionally substituted by one or more substituents selected from C1-3 alkyl, C1-3 alkoxy, C1-3haloalkyl, halogen, and optionally substituted phenyl; and (iii) a cycloalkyl group optionally substituted by one or more substituents selected from C1-3 alkyl, C1-3 haloalkyl, and halogen.
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