CELL-PENETRATING PEPTIDE CONJUGATES AND METHODS OF THEIR USE

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United States of America Patent

APP PUB NO 20240299563A1
SERIAL NO

18277013

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Abstract

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Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded or linked via a linker to the oligonucleotide, the peptide including at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, provided that the peptide includes a total of 7 to 40 amino acid residues and does not include any artificial amino acid residues; and the oligonucleotide including a total of 12 to 40 contiguous nucleobases, where at least 12 contiguous nucleobases are complementary to a target sequence in a human dystrophin gene.

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Patent Owner(s)

Patent OwnerAddress
UNITED KINGDOM RESEARCH AND INNOVATIONPOLARIS HOUSE NORTH STAR AVENUE SWINDON SN2 1FL

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ARZUMANOV, Andrey Cambridge, GB 3 0
BANERJEE, Subhashis Kolkata, IN 44 2631
GAIT, Michael Cambridge, GB 11 396
GODFREY, Caroline Oxford, GB 6 0
HAZELL, Gareth Didcot, GB 2 0
HOLLAND, Ashling Dublin, IE 6 0
MANZANO, Raquel Zaragoza, ES 3 0
MCCLOREY, Graham Oxford, GB 57 3533
O'DONOVAN, Liz Cork, IE 3 0
RAZ, Richard Copenhagen, DK 8 5
VARELA, Miguel Oxford, GB 4 0
WOOD, Matthew Oxford, GB 87 613

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