CANCER EARLY DETECTION METHOD USING LIQUID BIOPSY
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United States of America Patent
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Issued Date -
Aug 29, 2024
app pub date -
Apr 24, 2023
filing date -
Feb 24, 2023
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Abstract
The invention provides a cancer early detection method using liquid biopsy, the cancer early detection method includes the following steps. MicroRNA expression profile database of cancer patient populations and healthy populations are established. Afterwards, an analysis model for cancer early detection is established through the following steps: a data quality control, a technical replicate merging, a calculation of normalization factors and data normalization, a biomarker feature selection, and a hyperparameter tuning. The analysis model for cancer early detection includes normalization factors, a set of biomarkers, model weights and model hyperparameters. A microRNA expression profile in a liquid biopsy sample of a subject is analyzed by the analysis model for cancer early detection to be used as a basis for an early detection of cancer.
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