RECOMBINANT MICROORGANISM FOR PRODUCING CARNOSINE, HISTIDINE AND BETA-ALANINE AND METHOD FOR PRODUCING CARNOSINE, HISTIDINE AND BETA-ALANINE BY USING SAME
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United States of America Patent
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Issued Date -
Aug 29, 2024
app pub date -
May 6, 2022
filing date -
Apr 13, 2021
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Provided is a recombinant microorganism for producing carnosine, histidine and beta-alanine and a method for producing carnosine, histidine and beta-alanine by using same and, more particularly, to: a recombinant microorganism for high production of carnosine, histidine and beta-alanine produced through the redesign of metabolic pathways; a method for producing same; and a method for producing carnosine, histidine and beta-alanine by using same. According to the present invention, in a microorganism capable of producing histidine and beta-alanine, by enhancing the pentose phosphate pathways through the replacement of a pentose phosphate pathway-related operon gene with a highly expressing synthetic promoter and the replacement of a pgi gene with an initiation codon, and inducing enhancement of the production of histidine and beta-alanine through the overexpression of genes on histidine and beta-alanine metabolic pathways, respectively, it is possible to develop a recombinant microorganism for high production of histidine and beta-alanine.
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