DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF

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United States of America Patent

APP PUB NO 20240287129A1
SERIAL NO

18640494

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Abstract

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Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.

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Patent Owner(s)

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THE TRUSTEES OF PRINCETON UNIVERSITYONE NASSAU HALL PRINCETON NJ 08544

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
MacMillan, David Princeton, US 17 578
McCarver, Stefan Princeton, US 13 8
Novoa, Daniel New York, US 3 4

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