DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF
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United States of America Patent
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Issued Date -
Aug 29, 2024
app pub date -
Apr 19, 2024
filing date -
Jun 5, 2015
priority date (Note) -
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Abstract
Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
First Claim
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Family
Country | kind | publication No. | Filing Date | Type | Sub-Type |
---|---|---|---|---|---|
US | B2 | US11136349 | Jun 03, 2016 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
GRANTED PATENT AS SECOND PUBLICATION | Decarboxylative conjugate additions and applications thereof | Oct 05, 2021 | |||
WO | A1 | WO2016196931 | Jun 03, 2016 | Patent | Application |
Type : Patent Sub-Type : Application | |||||
INTERNATIONAL APPLICATION PUBLISHED WITH INTERNATIONAL SEARCH REPORT | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | Dec 08, 2016 | |||
US | B2 | US11981704 | Sep 08, 2021 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
GRANTED PATENT AS SECOND PUBLICATION | Decarboxylative conjugate additions and applications thereof | May 14, 2024 |
- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
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THE TRUSTEES OF PRINCETON UNIVERSITY | 87 PROSPECT AVENUE PRINCETON NJ 08544 |
International Classification(s)

- 2024 Application Filing Year
- C25B Class
- 401 Applications Filed
- 23 Patents Issued To-Date
- 5.74 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
MacMillan, David | Princeton, US | 17 | 578 |
# of filed Patents : 17 Total Citations : 578 | |||
McCarver, Stefan | Princeton, US | 13 | 8 |
# of filed Patents : 13 Total Citations : 8 | |||
Novoa, Daniel | New York, US | 3 | 4 |
# of filed Patents : 3 Total Citations : 4 |
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Patent Citation Ranking
- 0 Citation Count
- C25B Class
- 0 % this patent is cited more than
- 1 Age
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