COMPOSITIONS AND METHODS FOR ENHANCING CAR T CELL EFFICACY THROUGH THE ENGINEERED SECRETION OF C. PERFRINGENS NEURAMINIDASE

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United States of America Patent

APP PUB NO 20240285757A1
SERIAL NO

18292247

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Abstract

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The present invention provides compositions and methods comprising CAR T cells that secrete neuraminidase (e.g., C. perfringens neuraminidase (CpNA)). Compositions and methods of treatment are also provided.

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Patent Owner(s)

Patent OwnerAddress
UNIV PENNSYLVANIAPENN CENTER FOR INMOVATION 3160 CHESTNUT STREET SUITE 200 PHILADELPHIA PENNSYLVANIA 19104 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Durgin, Joseph Dexter, US 1 0
O'Connor, Roderick Philadelphia, US 6 28
O'Rourke, Donald M Wynnewood, US 14 113

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