SYSTEMS AND METHODS FOR ANTIBODY CHAIN PAIRING
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United States of America Patent
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Aug 22, 2024
app pub date -
Aug 5, 2022
filing date -
Aug 6, 2021
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Abstract
The present application relates to methods for determining antibody heavy and light chain pairing in an antibody and/or antibody fragment mixture. The methods include a step of submitting the mixture to a separation step under non-reducing condition to obtain isolated antibodies or antibody fragments, or of contacting the mixture with a protein cross-linking agent. The isolated or cross-linked antibodies and/or antibody fragments are then digested using one or more proteases to generate antibody or antibody fragment peptides, which are then analyzed for example by mass spectrometry (MS) to determining heavy chain and light chain pairing of the antibody or antibody fragment in the mixture.
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