POLYPEPTIDE NANOPORES SYNTHETICALLY FUNCTIONALIZED WITH POSITIVELY CHARGED SPECIES, AND METHODS OF MAKING AND USING THE SAME
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United States of America Patent
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Issued Date -
Aug 22, 2024
app pub date -
Mar 10, 2022
filing date -
Mar 31, 2021
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Abstract
Polypeptide nanopores synthetically functionalized with positively charged species, and methods of making and using the same, are provided herein. In some examples, a polypeptide nanopore includes a first side, a second side, a channel extending through the first and second sides, and a mutated amino acid residue. The mutated amino acid residue may be synthetically functionalized with a positively charged species that inhibits translocation of cations through the channel.
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