MARKER FOR DNA DAMAGE IN PROXIMITY OF TRANSCRIBED GENOMIC LOCI AND METHODS FOR IDENTIFYING AND/OR QUANTIFYING THESE DNA DAMAGES
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Aug 22, 2024
app pub date -
Jun 30, 2022
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Jul 1, 2021
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Abstract
The present invention relates to cyclin-dependent kinase, 12, CDK12 (cyclin-dependent kinase 12), for use as a marker for DNA damage in proximity of transcribed genomic loci in a sample, and to methods for identifying and/or quantifying in a sample DNA damage events associated to actively transcribed genomic loci, comprising detecting the CDK12 protein in proximity of the aforesaid genomic loci.
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