SYSTEM, DEVICE AND METHOD FOR PRODUCTION OF BIOPRODUCT INCLUDING HIGH DENSITY CELL RESPIRATOR (HDCR) FOR INTENSIFIED PRODUCTION OF ADENO-ASSOCIATED VIRUSES (AAV) AND CELL-BASED PRODUCTION
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United States of America Patent
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Issued Date -
Aug 22, 2024
app pub date -
Apr 10, 2024
filing date -
Nov 15, 2019
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Abstract
A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.
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