TRISPECIFIC AND/OR TRIVALENT BINDING PROTEINS
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United States of America Patent
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Aug 22, 2024
app pub date -
Feb 5, 2024
filing date -
Apr 13, 2016
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The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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