ANTIBODY FOR IDENTIFYING PHOSPHORYLATION-SPECIFIC REACTIONS OF THREONINE AT POSITION 1010 OF NCAPG2, AND USE THEREOF
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Issued Date -
Aug 22, 2024
app pub date -
May 24, 2022
filing date -
May 25, 2021
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Abstract
The present invention relates to an antibody for identifying phosphospecific reactions of threonine at position 1010 in the amino acid sequence of non-SMC condensin II complex subunit G2 (NCAPG2), and a use thereof. It has been identified that: an antibody for identifying whether threonine at position 1010 in the amino acid sequence of NCAPG2 is phosphorylated, according to the present invention, has high selectivity and avidity with respect to pT1010 of NCAPG2; the reactivity thereof to pT1010 of NCAPG2 is inhibited in cancer cells treated with inhibitors of kinases for regulating cellular mitosis phase, such as CDK1, PLK1, Mps1, and aurora kinase; and detection of the antibody is far higher in tumor tissues than non-tumor tissues of a cancer patient through immunohistochemical staining. Therefore, it is expected that identifying the phosphorylation of threonine at position 1010 of NCAPG2 through the antibody, according to the present invention, can be effectively used in cancer-related research and development fields such as that of diagnosing cancer or screening for anticancer drug candidates.
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