POLYPEPTIDE CONJUGATE AND APPLICATION THEREOF IN PREPARATION OF DRUG FOR TREATING DISEASES RELATED TO GLUCOSE METABOLISM
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Aug 22, 2024
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Jul 20, 2022
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Jul 20, 2021
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Abstract
The present invention belongs to the field of medicine, and the present invention relates, in particular, to a polypeptide conjugate and an application of a polypeptide conjugate in the preparation of a drug for treating diseases related to glucose metabolism. The polypeptide conjugate of the present invention is formed by conjugating a glucagon mutant with one or more polyethylene glycols. The polypeptide conjugate can rapidly increase the blood glucose level within the body and maintain for a long time a stable blood glucose level within the body. The present invention is suitable for the treatment of congenital hyperinsulinism and various types of hypoglycemic disorders.
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