RECOMBINANT NEWCASTLE DISEASE VIRUS AND PREPARATION METHOD THEREFOR, RECOMBINANT PLASMID, AND USE THEREOF
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United States of America Patent
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Issued Date -
Aug 15, 2024
app pub date -
May 21, 2021
filing date -
Mar 30, 2020
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A recombinant Newcastle disease virus and a preparation method therefor, a recombinant plasmid, and use of the recombinant Newcastle disease virus or the recombinant plasmid. The recombinant Newcastle disease virus is obtained by replacing an F protein of a Newcastle disease virus lasota with an F protein encoded by a DNA as set forth in SEQ ID NO: 1 at positions 7274-8935 from a 5′-terminus. The recombinant Newcastle disease virus is safe and capable of effectively inhibiting tumour cells and promoting tumour cell apoptosis.
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