METHODS DIRECTED TO CRYSTALLINE BIOMOLECULES
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United States of America Patent
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Aug 15, 2024
app pub date -
Mar 13, 2024
filing date -
Mar 14, 2017
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Abstract
Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.
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