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Abstract

The discovery is of a cooling molecule and its formulation as a topical medication for treatment of skin dysesthesia in hair-coated mammals. Hair-coated mammals such as dogs are seldom treated with topical medications because the hair on the skin and the stratum corneum prevents drug access to receptors in the epidermis. In screening cooling agents for their actions in the oral cavity and throat in humans, a FEMA (Flavor Extract Manufacturers Association) entity, registered for use in chewing gum and hard candy, produced an acute stinging and painful cold, like ice chips in the throat, which was long-lasting. These actions suggested that it might have anti-itch properties. The FEMA entity was formulated as a topical gel or as a liquid, and these formulations relieved skin itch in humans and dogs without causing any skin injury. The duration of the cooling action, ≥3 hr, was sufficient to be therapeutically effective. In dogs, the FEMA entity relieved itchy stimuli from the inflammation of allergies and stopped scratching behavior in subjects with canine dermatitis. Other related FEMA cooling agents used in the oral cavity as comestibles or in toiletries such as WS-3, WS-5, WS-12, and WS-23 were ineffective in the therapeutic relief of canine dysesthesia primarily because of a limited duration of action. Topical formulations for cooling relief of skin dysesthesia in hair-coated mammals represent a new strategy for treatment.

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First Claim