DETERGENTS AND METHODS
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United States of America Patent
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Issued Date -
Aug 8, 2024
app pub date -
May 11, 2022
filing date -
May 11, 2021
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Abstract
A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a hybrid detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source; vaporising the solution; ionising the protein; resolving the ionised protein; and detecting the resolved protein. The mass spectrometry methods may be used to interrogate the lipidome of a protein of interest, and/or for analysing membrane proteins in the form of complexes with ligands, and in particular lipids.
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