METHODS OF TREATING DISEASES ASSOCIATED WITH ELEVATED URIC ACID
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United States of America Patent
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Aug 8, 2024
app pub date -
Feb 1, 2024
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Feb 2, 2023
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Abstract
A method of treating a disease or disorder associated with excessive uric acid levels is disclosed herein. The method comprises administering to the subject by i.v. infusion an amount of a recombinant homotetrameric uricase enzyme comprising four uricase polypeptides having the amino acid sequence as set forth in SEQ ID NO: 2, wherein the polypeptides are crosslinked by polyethylene glycol (PEG) bis-aldehyde having a molecular weight of 2-3.5 kDa.
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