Enhanced Q1 Mass Segregation in Scanning SWATH
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United States of America Patent
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Issued Date -
Aug 1, 2024
app pub date -
Jun 2, 2022
filing date -
Jun 9, 2021
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Abstract
During each time cycle, a precursor ion transmission window is stepped in k overlapping steps that are Δm m/z apart entirely across a mass range from a starting mlm/z. The window is stepped n−1 more times starting at n−1 different offsets from ml between ml and ml+Δm. A total of n scans of the mass range. A total of k×n product ion spectra are produced that are a function of precursor ion m/z for each time cycle. A product ion is selected from the spectra. For at least one time cycle, an intensity of the product ion as a function of precursor ion m/z is reconstructed with a resolving power greater than Δm by combining intensities of the product ion measured during each of the n scans using a linear reconstruction algorithm, such as Drizzle.
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