DIFFERENTIATION OF COINFECTION FROM CONTAMINATION WITHIN GENETIC SAMPLES
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United States of America Patent
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Issued Date -
Aug 1, 2024
app pub date -
Jan 27, 2023
filing date -
Jan 27, 2023
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Abstract
Various embodiments disclosed relate to a method for detection of coinfection of two or more pathogen variants in an individual. The present disclosure includes methods of receiving a biological sample, selecting a first variant of the pathogen and a second variant of the pathogen, sequencing the biological sample, calculating a composite alternative allele fraction, and if the sample is a mixed sample, searching individual reads to detect a recombinant pathogen.
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