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• 15 United States
• 10 France
• 8 Japan
• 7 China
• 5 Korea
• 2 Other

Patent Owner(s)

Patent Owner	Address
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES	6011 EXECUTIVE BOULEVARD SUITE 325 MSC 7660 BETHESDA MD 20892-7660

International Classification(s)

• C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
• C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
• G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....

• 2024 Application Filing Year
• C12Q Class
• 1740 Applications Filed
• 69 Patents Issued To-Date
• 3.97 % Issued To-Date

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
Agarwal, Suneet	Belmont, US	50	770
# of filed Patents : 50 Total Citations : 770
Iyer, Aravind	Bethesda, US	42	837
# of filed Patents : 42 Total Citations : 837
Koh, Kian Peng	Jamaica Plain, US	39	747
# of filed Patents : 39 Total Citations : 747
Rao, Anjana	La Jolla, US	75	871
# of filed Patents : 75 Total Citations : 871
Tahiliani, Mamta	New York, US	39	747
# of filed Patents : 39 Total Citations : 747

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3.5 Year Payment	$1600.00	$800.00	$400.00	Feb 1, 2028
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Full Text

US Patent Application No: 2024/0254,542

SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS

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Abstract

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The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TEM3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.

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Description

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