TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS
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United States of America Patent
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Issued Date -
Jul 25, 2024
app pub date -
Jan 10, 2024
filing date -
Apr 11, 2016
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Abstract
The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
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