COMPOSITIONS COMPRISING EXTRACELLULAR VESICLES AND AN ACTIVE AGENT AND USES THEREOF
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Issued Date -
Jul 25, 2024
app pub date -
May 25, 2022
filing date -
May 25, 2021
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Abstract
The present disclosure provides a composition comprising an extracellular vesicle (EV) associated with an active agent and a polymer, wherein said polymer carries at least one positively charged moiety or has at least one positive pole and said active agent carries, independently, at least one negatively charged moiety or has at least one negative pole; and wherein said polymer and said active agent are present at a positive to negative charge or pole ratio of at least 2. A preferred example relates to a composition wherein the polymer is polyethyleneimine, the agent is a nucleic acid and the EV is an exosome. The present disclosure also provides methods for obtaining the composition and uses of the composition.
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