Inhibition of Lysine Demethylase 1 (Lsd1) Induces Differentiation of Hair Cells

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United States of America Patent

APP PUB NO 20240245702A1
SERIAL NO

18491200

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Abstract

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Methods for the generation of sensorineural hair cells, and more particularly to the use of epigenetic modulation of Atoh1 expression using a combination of Histone Lysine Demethylase (KDM) inhibitors and Wnt activators to generate sensorineural hair cells.

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Patent OwnerAddress
MASSACHUSETTS EYE AND EAR INFIRMARY243 CHARLES STREET BOSTON MA 02114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Edge, Albert Brookline, US 56 429
Gunewardene, Niliksha Boston, US 2 1

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