COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS USING A CD14 INHIBITOR

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United States of America Patent

APP PUB NO 20240239913A1
SERIAL NO

18411242

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are methods of treating or preventing the development of osteoarthritis after a joint injury by administering a CD14 inhibitor capable of neutralizing or blocking CD14, inhibiting CD14 function, inhibiting CD14 production, or a combination thereof. Also disclosed herein are methods of reducing or ameliorating one or more symptoms of osteoarthritis, reducing inflammation, reducing cartilage degradation, or treating or preventing subchondral bone sclerosis in a subject.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA3160 CHESTNUT STREET SUITE 200 PHILADELPHIA PA 19104
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS810 VERMONT AVENUE NW WASHINGTON DC 20420

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GRIFFIN, TIMOTHY Oklahoma City, US 49 1925
SCANZELLO, CARLA R Philadelphia, US 2 1

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