RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF

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United States of America Patent

APP PUB NO 20240239810A1
SERIAL NO

18584888

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Abstract

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The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocycles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITYAPPLIED PHYSICS LABORATORY JOHNS HOPKINS ROAD LAUREL MD 20723-6099

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hong, Sam Baltimore, US 12 20
Kumar, Puneet Baltimore, US 46 1234
Liu, Jun Clarksville, US 1497 18125
Sadagopan, Magesh Baltimore, US 6 2
Schmitt, Jennifer C Baltimore, US 5 2
Semple, Joseph E Baltimore, US 19 114
Ullman, Brett R Baltimore, US 10 82
Yamamoto, Kana Baltimore, US 26 110

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