COMPOUNDS FOR TREATING CONDITIONS RELATED TO PCSK9 ACTIVITY
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United States of America Patent
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Issued Date -
Jul 18, 2024
app pub date -
Aug 18, 2022
filing date -
Aug 19, 2021
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Abstract
The present disclosure provides a method of treating hypercholesterolemia and other conditions related to PCSK9 activity, e.g. atherosclerosis, atherosclerotic cardiovascular disease, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions, by orally administering to the subject an amount of a compound of formula (I) wherein A″ is selected from a pharmaceutically acceptable anion, and wherein the amount administered is from about 5 mg to about 300 mg of the compound of formula (I). The present invention is also directed to pharmaceutical compositions comprising a compound of formula (I), including particular salts of a compound of formula (I), and a permeation enhancer.
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