MODIFIED ORTHOPOXVIRUS VECTORS
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United States of America
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Issued Date -
Apr 25, 2024
app pub date -
Sep 5, 2023
filing date -
Sep 5, 2023
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Abstract
The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.
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