MICROFLUIDIC MODEL OF THE BLOOD BRAIN BARRIER
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United States of America Patent
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Issued Date -
Jul 11, 2024
app pub date -
Dec 5, 2023
filing date -
Oct 19, 2015
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Abstract
The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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