STEREOSELECTIVE C9-C10 BOND FORMATION
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United States of America Patent
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Jul 11, 2024
app pub date -
Apr 14, 2022
filing date -
Apr 20, 2021
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Abstract
The present disclosure relates to synthetic methods for preparing a 9-alpha-substituted or a 9-beta-substituted steroid-like compound. In particular, the disclosure relates to methods for generating a steroidal C9-C10 bond and establishing stereochemistry at C9 in such compounds. The methods provide high levels of stereoselection in the C9-C10 bond forming process. Compounds synthesized by such methods can be used as nuclear hormone receptor modulators.
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