RECOMBINANT YEASTS FOR PRODUCING ACETONE AND/OR ISOPROPANOL FROM FATTY ACID FEEDSTOCKS
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United States of America Patent
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Issued Date -
Jul 4, 2024
app pub date -
May 11, 2022
filing date -
May 12, 2021
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Abstract
Recombinant yeasts bioengineered to overexpress genes for utilization of fatty acids to produce acetone and isopropanol, and methods of use thereof. The yeasts are modified to express, constitutively express, or overexpress an acetyl-CoA thioesterase, an acetyl-CoA C-acetyltransferase, an acetoacetyl-CoA transferase, an acetoacetyl-CoA thioesterase, an acetoacetate decarboxylase, an isopropanol dehydrogenase, or any combination thereof. The methods include cultivating the recombinant yeasts to convert any fatty acid-containing feedstocks into acetone and/or isopropanol.
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