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Abstract

In some embodiments, the present disclosure pertains to multi-arm polymers having at least one polymer arm that comprises a reactive radiopaque end moiety. The radiopaque end moiety comprises a radiopaque dicarboxylic acid ester moiety containing one or more radiopaque atoms, wherein one of two ester groups of the radiopaque dicarboxylic acid ester moiety forms a link to the polymer arm, and wherein the other of the two ester groups of the radiopaque dicarboxylic acid ester moiety corresponds to a portion of a reactive electrophilic group. The present disclosure also pertains to methods of forming such multi-arm polymers and to hydrogels formed from such multi-arm polymers and a polyamino compound comprising a plurality of primary amine groups that form crosslinks with the multi-arm polymers. The present disclosure further pertains to methods and systems for forming such hydrogels and methods of treatment using such hydrogels.

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First Claim