MOLECULES WITH ENGINEERED ANTIBODY CONSTANT REGION VARIANTS
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United States of America Patent
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Jul 4, 2024
app pub date -
Apr 18, 2022
filing date -
Apr 19, 2021
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Abstract
A binding molecule comprising (i) a first polypeptide comprising a heavy chain variable region (VH) and a region derived from the first constant region of an antibody heavy chain (CH1), and (ii) a second polypeptide comprising a light chain variable region (VL) and a region derived from the constant region of an antibody light chain (CL), wherein the region derived from the CH1 region and/or the region derived from the CL region comprises one or more antigen binding loop(s).
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