METHODS OF SCREENING AND EXPRESSION OF DISULFIDE-BONDED BINDING POLYPEPTIDES
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United States of America Patent
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Issued Date -
Jul 4, 2024
app pub date -
May 11, 2022
filing date -
May 12, 2021
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Abstract
The present disclosure relates to methods of producing and screening display libraries of disulfide-bonded binding polypeptides, for instance to identify binding peptides specific for a target molecule. In some embodiments, the binding peptides comprise an ultralong CDR3. The binding peptides can be derived from a bovine antibody comprising an ultralong CDR3, or they can be synthetic or semisynthetic. Also provided herein are display libraries comprising disulfide-bonded binding polypeptides. The present disclosure also relates to methods of producing or expressing soluble disulfide-bonded binding polypeptides, for instance using a suitable host cell. Also provided herein are compositions comprising soluble disulfide-bonded binding polypeptides.
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