MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES

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United States of America Patent

APP PUB NO 20240218041A1
SERIAL NO

18288925

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A two-chain insulin analogue is provided containing (a) a B chain modified by the addition of a C-terminal diol element in combination with (b) a glucose-binding element attached to the A chain at or near its N terminus, optionally linked to a D-amino acid. A “flipped” set of insulin analogues wherein the A chain is modified by addition of an N-terminal diol element whereas the glucose-binding element is attached at or near the C terminus of the B chain is also provided. Compositions comprising such insulin analogues are used in methods of treating a patient with diabetes mellitus.

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THE TRUSTEES OF INDIANA UNIVERSITY107 S INDIANA AVE BLOOMINGTON IN 47405

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
JAROSINSKI, Mark A Fishers, US 7 8
WEISS, Michael A Indianapolis, US 34 196

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges377110801 - 1002505007501000125015001750200022502500275030003250350037504000

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