EXPRESSION AND ENHANCED SECRETION OF ACTIVE MORINGA OLEIFERA COAGULANT PROTEIN IN BACILLUS

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United States of America Patent

APP PUB NO 20240218028A1
SERIAL NO

16582436

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Abstract

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A system and method for producing a recombinant Moringa oleifera coagulant protein (MO) in Bacillus includes the expression of a recombinant nucleic acid encoding the MO protein fused or linked to a Bacillus signal peptide (SP). The nucleic acid can also be modified by codon optimization for enhanced expression of the MO protein in bacteria. The recombinant MO protein has coagulation/flocculation activity and can be used in the treatment of contaminated water, particularly drinking water. Vectors and nucleic acid constructs encoding the MO protein and SP, and host bacterial cells are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
US ARMYABERDEEN PROVING GROUNDS MD

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  • 2019 Application Filing Year
  • C12R Class
  • 167 Applications Filed
  • 65 Patents Issued To-Date
  • 38.93 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances20192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnett, Clint M Mahomet, US 5 9
Boyd, Ashley N Champaign, US 3 0
Cropek, Donald M Champaign, US 8 13
Lange, Justin Mahomet, US 35 74
Page, Martin A Urbana, US 5 0

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