SYSTEMS, METHODS, AND DEVICES FOR EX VIVO ANALYSIS OF RESECTED TISSUE SAMPLES
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United States of America Patent
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Issued Date -
Jun 27, 2024
app pub date -
Mar 9, 2021
filing date -
Mar 12, 2020
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Abstract
Ex vivo analysis can be performed by mounting a portion of live tissue resected from a patient on a sample platform. Using the sample platform, the resected tissue portion can be positioned within a perfusion chamber. Perfusate is flowed through the perfusion chamber and into contact with the resected tissue portion such that diffusion of oxygen occurs between the perfusate and the resected tissue portion. During the flowing, the resected tissue portion maintains a competent immune system. Drugs can be added to the perfusate flow to ascertain the effect on the tissue. The sample platform is designed to be removable from the perfusion chamber for analysis of the tissue by imaging or other investigation techniques, for experimental treatment, or for any other purpose. After removal, the sample platform can be returned to the perfusion chamber for continued viability of the tissue.
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