METHOD OF INCREASING CHAPERONE MEDIATED AUTOPHAGY BY STABILIZING THE INTERACTION OF RETINOIC ACID RECEPTOR-ALPHA AND AN INHIBITOR
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United States of America Patent
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Issued Date -
Jun 27, 2024
app pub date -
Apr 21, 2022
filing date -
Apr 21, 2021
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Abstract
This disclosure provides a method of stabilizing the interaction of a Retinoic Acid Receptor-alpha (RARα) and a corepressor, Nuclear Receptor Corepressor 1 (NCoR1) by contacting the RARa with an amount of a Chaperone Mediated Autophagy (CMA) Activator sufficient to stabilize the RARα-NCoR1 interaction. Stabilizing the RARα/corepressor interaction can prevent a neurodegenerative disorder in a subject at risk for developing the neurodegenerative disorder or slow the advancement of a neurodegenerative disorder in a subject having an early symptom or biomarker of the neurodegenerative disorder. The disclosure also provides a method of maintaining preventing or slowing the advancement of a retinal degenerative disorder in a subject having an early symptom or biomarker of the retinal degenerative disorder. The neurodegenerative disorder can be Alzheimer's disease (AD), Lewy body dementia, Parkinson's disease (PD), Huntington's disease, Amyotrophic lateralsclerosis (ALS), Frontotemporal dementia (FTD), Spinocerebellar ataxias (SCAs). The retinal degenerative disorder can be retinitis pigmentosa.
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