COMPOSITIONS AND METHODS FOR TREATING INDIVIDUALS WHO HAVE ONCOGENE-NEGATIVE CANCER
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Issued Date -
Jun 20, 2024
app pub date -
Apr 29, 2022
filing date -
Apr 29, 2022
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Methods and compositions are provided for treating individuals who have an oncogene-negative cancer. In some cases, such individuals have an oncogene-negative tumor(s). In some cases, they have an oncogene-negative lung cancer. In some cases, they have an oncogene-negative lung adenocarcinoma. In some cases, treatment includes administering an inhibitor of the Ras/MAPK pathway. In some cases, treatment includes administering an inhibitor of the Ras/MAPK pathway and an inhibitor of the PI3K-AKT pathway. Methods and compositions are also provided for testing candidate cancer therapeutics. In some cases, such methods include contacting an oncogene-negative cell, in culture or in vivo, with a candidate agent, where the cell has increased Ras/MAPK pathway activity and/or increased PI3K-AKT pathway activity.
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