METHOD FOR PRODUCING ANTIBODY-DRUG CONJUGATE AND ENZYME USED FOR THE SAME
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United States of America Patent
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Issued Date -
Jun 13, 2024
app pub date -
Mar 31, 2022
filing date -
Mar 31, 2021
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Abstract
A simpler ADC production method is provided. A method for producing an antibody-drug conjugate including the following step: the step of conjugating a glycan-homogenized antibody and a glycosylated drug. The glycosylated drug consists of a drug bound to a glycan having an oxazolinated reducing end via a linker. The glycan-homogenized antibody and the glycosylated drug can be conjugated with an endo-P-N-acetylglucosaminidase mutant enzyme.
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