ARTIFICIAL KETOREDUCTASE VARIANTS AND THE DESIGN METHODOLOGY THEREOF
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United States of America Patent
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Jun 6, 2024
app pub date -
Apr 20, 2022
filing date -
May 3, 2021
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Abstract
The present invention provides ketoreductase variants having activity on both (R)-(−)-1,3-butanediol and (S)-(+)-1,3-butanediol, and the computational methodology for designing the above mentioned ketoreductase variants. The ketoreductase variants disclosed in the present application can catalyze the reaction of synthesizing 4-hydroxy-2-butanone from racemic 1,3-butanediol, which has industrial application prospects.
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