METHODS AND COMPOSITIONS FOR DETECTION OF TUMOR DNA
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United States of America Patent
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Jun 6, 2024
app pub date -
Mar 30, 2022
filing date -
Mar 30, 2021
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This disclosure provides a method and compositions for substantially increasing the concentration of DNA in macrophages of a patient. By administering to a patient one or more agents which prevent the activity of deoxyribonucleases within lysosomes of macrophages, degradation of DNA phagocytosed by macrophages is temporarily blocked, permitting its accumulation. This strategy has the potential to enhance the detection of genetic biomarkers from cells typically phagocytosed by macrophages, such as tumor cells, and thus has applications for early or residual detection of cancer.
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