SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS

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United States of America Patent

APP PUB NO 20240182469A1
SERIAL NO

18488871

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Abstract

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The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gretzke, Dirk Frankfurt am Main, DE 19 128
Heinelt, Uwe Frankfurt am Main, DE 54 495
Ritzeler, Olaf Frankfurt am Main, DE 27 269
Schmidt, Friedemann Frankfurt am Main, DE 12 42
Wehner, Volkmar Frankfurt am Main, DE 73 535

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