MAP4K1 INHIBITORS

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United States of America Patent

APP PUB NO 20240174683A1
SERIAL NO

18275978

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

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Patent Owner(s)

Patent OwnerAddress
BAYER AKTIENGESELLSCHAFTKAISER-WILHELM-ALLEE 1 LEVERKUSEN 51373

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BÖMER, Ulf Glienicke/Nordbahn, DE 100 553
BERNDT, Sandra Hohen Neuendorf, DE 31 183
BUCHMANN, Berndt Hohen Neuendorf, DE 1 0
CARRETERO, Rafael Heidelberg, DE 9 0
CHEN, Peng Xian City, CN 449 2483
EAGLING, Louise Berlin, DE 1 0
FRIBERG, Anders Berlin, DE 1 0
GÜNTHER, Judith Berlin, DE 32 373
KOSEMUND, Dirk Berlin, DE 75 269
KUHNKE, Lara Berlin, DE 1 0
LÜCKING, Ulrich Berlin, DE 44 129
LEDER, Gabriele Berlin, DE 6 11
LEFRANC, Julien Darmstadt, DE 12 48
MÜLLER, Steffen Mülheim an der Ruhr, DE 15 31
MOWAT, Jeffrey Stuart Antwerp, BE 5 0
NEUHAUS, Roland Berlin, DE 44 180
NOWAK-REPPEL, Katrin Berlin, DE 17 28
OFFRINGA, Rienk Heidelberg, DE 35 134
ONDOZABAL, Hideki Miyatake Berlin, DE 2 0
OSMERS, Maren Dallgow-Döberitz, DE 4 3
SCHÄFER, Martina Berlin, DE 39 170
SITNIKOV, Nikolay Schulzendorf, DE 7 0
STOECKIGT, Detlef Potsdam, DE 4 2
THEDE, Kai Berlin, DE 56 219
WANG, Xuewei Xian City, CN 18 56
WENGNER, Antje Margret Berlin, DE 56 135
WOHLFAHRT, Gerd Berlin, DE 28 129
WORTMANN, Lars Biberbach an der Riß, DE 44 179
YAN, Yuanyuan Xian City, CN 4 6
ZORN, Ludwig Berlin, DE 58 394

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