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Abstract

Methods for the treatment of diseases involving autophagy by leukocytes, preferably neutrophil cells, which process, according to the disclosure, is involved in mechanisms of tissue repair, vascular permeability and immune responses. The disclosure provides methods and means to target a chemoattractant receptor, preferably a leukocyte cell-surface receptor specifically and to provide molecules and compositions comprising a specific targeting agent as well as amino acid compositions that are involved in the pathway of autophagy and the diseases related thereto. The disclosure also relates to peptide drug development, in particular, to (the improvement of) autophagy inhibiting amino acid containing peptides, more in particular, glutamine-containing peptides and/or glutamine and other autophagy-modulating amino acid containing compositions useful in the treatment of vascular and inflammatory conditions.

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First Claim