COMPOSITION AND METHOD FOR THREE-DIMENSIONAL HISTOLOGICAL STAINING
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United States of America Patent
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Issued Date -
May 23, 2024
app pub date -
Nov 16, 2023
filing date -
Nov 17, 2022
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Abstract
This disclosure presents a composition for tissue staining and 3D specimen optical clearing, along with a method of making biological material transparent and labeling it simultaneously. The composition includes an amide dye adjuvant, a RI-matching material, a permeating agent, a labeling material, a mixture homogeneity excipient, and a solvent with DMSO. The RI-matching material includes a contrast agent and sugar. The composition has a neutral or acidic pH. The method involves fixing a specimen with a fixative solution and immersing and incubating the specimen in the composition for permeation. This disclosure also presents a kit for rendering biological material transparent. The kit is helpful for experimental animal/human histological studies and cancer staging/tumor differentiation determination.
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