NUCLEIC ACID TEMPLATE FOR DETECTION OF TARGET NUCLEIC ACID BASED ON G-QUADRUPLEX SEQUENCE AND USE THEREOF
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Issued Date -
May 23, 2024
app pub date -
Apr 15, 2022
filing date -
Apr 15, 2021
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Abstract
The present invention relates to a nucleic acid template for detection of a target nucleic acid based on a G-quadruplex sequence and a use thereof. A nucleic acid template for detection of a target nucleic acid or a method for detection or diagnosis of a target nucleic acid, using same according to the present invention, allows for simple and rapid detection of a target nucleic acid at room temperature with high specificity through addition and reaction of a reaction enzyme even without a separate PCR machine or a complicated temperature control procedure. In addition, the template and the method exhibit high detection sensitivity because of taking advantage of rolling circle amplification or rolling circle transcription based on circular ring formation to amplify signals, and can instantly detect a target nucleic acid even without expensive signaling substances such as fluorescent molecules, or a separate signal detection procedure such as electrophoresis because of visibly forming a gel in the presence of the target nucleic acid. Therefore, the template and the method are useful in various fields such as infectious diseases, cancer diagnosis, hereditary disease, and customized diagnosis.
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