LIPIDS SUITABLE FOR NUCLEIC ACID DELIVERY
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United States of America Patent
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Issued Date -
May 23, 2024
app pub date -
Feb 2, 2022
filing date -
Feb 2, 2021
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Abstract
The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
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