MOLECULAR MARKER FOR DIAGNOSING PRIMARY BILIARY CHOLANGITIS AND METHOD FOR DETECTING SAME
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United States of America Patent
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May 16, 2024
app pub date -
Apr 20, 2022
filing date -
Nov 19, 2021
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Abstract
A molecular marker for diagnosing primary biliary cholangitis and a method for detecting same are provided. The anti-human multimer immunoglobulin receptor antibody is adopted as the primary biliary cholangitis diagnosis molecular marker so as to prepare the diagnosis reagent; the human multimer immunoglobulin receptor antibody is remarkably increased in serum of PBC AMA-M2 subtype positive and negative patients, which indicates that in the attack of PBC, the serum anti-human multimer immunoglobulin receptor antibody specifically targets human multimer immunoglobulin receptors on small and medium bile ducts in the liver, thereby causing damage to the small and medium bile ducts.
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