MULTIMERIC CHELATOR COMPOUNDS FOR USE IN TARGETED RADIOTHERAPY

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United States of America Patent

APP PUB NO 20240156999A1
SERIAL NO

18275375

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Abstract

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The present invention covers compounds of general formula (I): [(C)n-L]-(V)m (I) where C is a chelator and n>1, L is a multi-functional linker moiety comprising multiple functional groups for the covalent attachment of chelator such as a polyamine or polyacid-containing backbone or amino acid containing polymer comprising side-chains with amino, thiol or carboxylic acid moieties such as lysine, cysteine or glutamic acid and V is a tissue targeting moiety where m=1-5 which preferentially coupled through a coupling moiety to either the multifunctional linker moiety L or directly to the chelator moiety C, and stereoisomers, tautomers, N-oxides, hydrates, solvates, and salts thereof, and mixtures of same.

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Patent Owner(s)

Patent OwnerAddress
BAYER AKTIENGESELLSCHAFTLEVERKUSEN

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BRUMBY, Thomas Berlin, DE 34 193
CRUCIANI, Véronique Oslo, NO 1 0
CUTHBERTSON, Alan Oslo, NO 103 1205
INDREVOLL, Bård Oslo, NO 3 3
KRISTIAN, Alexander Oslo, NO 2 2
KROGSTIE, Vilde Roko Oslo, NO 1 0
RAFIQUE, Waqas Oslo, NO 2 1

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